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There is one reason why we are dedicated to creating oral enzymes to treat metabolic diseases: You. Allena is committed to delivering targeted therapies that may help you find relief in the everyday battle with your condition.

About Enteric Hyperoxaluria

Hyperoxaluria is a condition in which there are high levels of oxalate in the urine. Oxalate is found naturally in foods like spinach, nuts, chocolate, and tea. It is also a normal byproduct of metabolism. Normally, the excess oxalate is removed by the kidneys through your urine. However, when there is too much oxalate in your urine, it can form crystals that may cause inflammation or grow into kidney stones.

Some people’s livers make too much oxalate due to a genetic condition called primary hyperoxaluria. Another kind of hyperoxaluria occurs in people with an underlying malabsorptive gastrointestinal (GI) condition that leads to absorption of too much oxalate from foods—this is called enteric hyperoxaluria. People can develop enteric hyperoxaluria due to complications from gastric bypass surgeries or surgery to remove part of the intestine. GI conditions like Crohn’s disease, ulcerative colitis, and disorders of the pancreas due to cystic fibrosis or pancreatitis can also cause enteric hyperoxaluria.

How Allena can help

Currently there are no approved treatments for enteric hyperoxaluria. Our investigational product reloxaliase is an oral enzyme that breaks down oxalate within the GI tract and helps reduce the burden on the kidney. In a clinical trial, reloxaliase was well tolerated with no serious adverse events.

If you suffer from frequent kidney stones and are looking for potential new ways to prevent them from returning, you may want to consider participating in the UriROX-2 Study.

man talking with doctor - hyperuricemia section

For additional information about hyperoxaluria,
please visit the Oxalosis & Hyperoxaluria Foundation.

man holding wrist - hyperuricemia and gout section

For more information about Hyperuricemia and Gout, visit MedlinePlus.

About Hyperuricemia and Gout

Hyperuricemia is an excess of urate in the blood. The body produces urate when it breaks down purines—substances that are found naturally in the body. Purines are also found in foods such as red meat, shellfish, and alcoholic beverages. Fructose, a “simple sugar” found in honey, fruit, and sweetened beverages, increases purine metabolism, which can also raise blood urate levels.

Elevated urate in the blood can lead to kidney stones and the formation of needlelike crystals in the joints. These crystals can lead to “gouty flares” of the joints and can result in kidney stones.

How Allena can help

Our product ALLN-346 is a first-in-class formulation of an enzyme that breaks down urate in the intestinal tract. It has the potential to reduce the burden on the kidney and lower the risk of gouty arthritis, gout attacks, and kidney stones.

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Jerome Gangitano

Vice President of Manufacturing and Process Development

Jerome Gangitano is the Vice President of Manufacturing and Process Development at Allena Pharmaceuticals. He is an experienced operations executive with more than 30 years of experience in the pharmaceutical and device industries. He has developed, commercialized, and supplied numerous products.

Prior to joining Allena, Jerome was a Site Head at Sanofi where he led a site including Safety and Environmental, Quality, Manufacturing, Process Development – MSAT; Facilities-Engineering, Supply Chain, Materials Purchasing, and Operational Excellence. Prior to his time at Sanofi, Jerome held various leadership positions in Operations, Manufacturing, and Quality at Genzyme, Focal, Johnson & Johnson, and Multiple Peptide Systems. Jerome received his BS in Chemistry from San Diego State University.

Kevin Brennan

Vice President, Finance

Kevin Brennan is the Vice President Finance at Allena Pharmaceuticals. Kevin joined the Allena team in 2011 as the Associate Director, Finance and has played an integral role in financial strategy, planning and operations, and the development and monitoring of systems designed to manage the organization’s finance and reporting. Kevin brings over twenty years of experience in the life science industry. Prior to joining Allena, Kevin held various positions at Alnara Pharmaceuticals, Altus Pharmaceuticals, and Genzyme, where he worked cross-functionally to drive strategic initiatives and optimize planning and reporting processes.

Kevin holds a B.S. in Accounting from Boston College.

Stephen Yu

Senior Vice President, Corporate Quality

Stephen Yu is Senior Vice President of Corporate Quality at Allena Pharmaceuticals. Stephen provides leadership for the internal Quality Assurance and Quality Control functions and oversight across internal and external GxP activities for Allena’s programs and facilities.

Stephen brings over 40 years of drug development and commercialization experience in technical and quality compliance roles. Over the past year, he has worked as Senior Vice President of Quality at Lyndra Therapeutics, a private company based in Watertown. In addition to serving previously as Vice President of Quality Assurance at Allena, Stephen has led his self-directed consultancy, Sky Pharma Consulting, and held prior roles as Vice President of Corporate Quality at Immunogen, as well as roles in Quality and Manufacturing at Genzyme, Merck & Co and Schering-Plough Research Institute.

Stephen earned a B.S. in Chemical Engineering from M.I.T. and an M.B.A. from Rutgers University.

Richard Katz, M.D.

Chief Financial Officer

Richard Katz, M.D. has served as chief financial officer since January 2021. Richard brings to Allena more than 20 years of experience in healthcare finance and corporate development.

Prior to joining Allena, Richard served as the chief financial officer of several biopharmaceutical companies, including Liquidia Technologies, Argos Therapeutics, Viamet Pharmaceuticals and Icagen, Inc. At Icagen, he played an instrumental role in the company’s initial public offering and subsequent financings, the formation of several strategic collaborations and the company’s sale to Pfizer. Richard began his career as a vice president in the healthcare investment banking group at Goldman, Sachs & Company, where he executed a broad range of transactions, including equity and debt financings, mergers and acquisitions, and corporate restructurings.

He holds a B.A. in applied mathematics from Harvard University, an M.D. from the Stanford University School of Medicine and an M.B.A. from Harvard Business School.

Alicja Januszewicz, PhD.

Vice President, People & Culture

Alicja Januszewicz, Ph.D., has served as the Head of People & Culture since 2019. Before joining Allena, she consulted with small organizations in Cambridge within talent management: employee development, organizational development, succession management, high potentials, and workforce planning. Previously, she had served as the Head of Talent Management at Baxalta Innovation Center, where she supported global R&D teams until the Shire acquisition.

Prior to joining Baxalta, Alicja served as Head of Talent Management at Epizyme and Boston Scientific HQ. She also supported the organizational development of Genzyme’s global HR manufacturing group.

Alicja holds a Ph.D. in Sociology from the Polish Academy of Science. She is a graduate of the Talent Management Institute, University of North Carolina, Kenan-Flagler Business School.

David J. Clark, M.D.

Chief Medical Officer

David J. Clark, M.D. has served as Chief Medical Officer since November 2020. He has over 20 years of global industry experience in biopharmaceutical companies based in the United States and Europe.

Before joining Allena, David served as the Chief Medical Officer of Aldeyra Therapeutics, a publicly-traded biotechnology company developing medicines for immune-mediated ocular and systemic diseases. He also served as Chief Medical Officer of Wilson Therapeutics, a privately-held biotechnology company developing novel pharmaceuticals to treat Wilson Disease, a rare autosomal recessive disorder of copper metabolism. David further served as Chief Medical Officer at NormOxys Inc. and TransTech Pharma, LLC. He has held leadership positions at a range of pharmaceutical companies including Pfizer, GlaxoSmithKline, and SmithKline Beecham.

David received his medical degree from the University of Edinburgh, trained in internal medicine, and conducted respiratory medicine academic research.

Geoffrey Swire

Acting Chief Operating Officer and Senior Vice President, Corporate Development

Geoffrey Swire joined Allena in 2018 and currently serves as Acting Chief Operating Officer and Senior Vice President, Corporate Development. Geoffrey has 20 years of leadership experience in business, product, and commercial development for life sciences companies.
 
Geoff previously worked at Radius Health, where he served as head of business development and alliance management, and earlier as program leader for the global Phase 3 osteoporosis development program. Prior to that, Geoff spent seven years at Genzyme, where he held various leadership positions in the Transplant and  Oncology business units, including as head of program and portfolio management, as well as vice president of global commercial operations. Geoff played a central role in the acquisition, development, regulatory approvals, and global commercial launch of Mozobil for patients undergoing stem cell transplants. He started his career in strategy and product development consulting at Integral, Inc., and Accenture’s Health & Life Sciences practice.

Geoff holds a B.A. in French and History from Dartmouth College and a Master’s in Public Policy from Harvard University

Hugh Wight

Senior Vice President, Technical Operations

Hugh Wight is senior vice president of technical operations at Allena Pharmaceuticals. He is an experienced manufacturing executive with more than 20 years in pharmaceutical and biopharmaceutical development, manufacturing, validation and quality assurance.

Prior to joining Allena, Hugh was vice president, technical operations for Alnara Pharmaceuticals, where he led manufacturing, project management, quality assurance and control, and fostered strategic partnerships with manufacturing organizations. Prior to his time at Alnara, Hugh held various quality assurance and validation leadership positions at Altus Pharmaceuticals, Alkermes, Aquila Biopharmaceuticals, AutoImmune and InSite Vision.

Hugh holds a B.S. in microbiology from the University of Maine-Orono.

Louis Brenner, MD

President and Chief Executive Officer

Lou Brenner, MD, has served as chief executive officer of Allena since February 2019 and as president since February 2017. He previously served as chief operating officer from April 2015 to January 2019.

Lou has more than a decade of industry leadership experience, including pharmaceutical development strategy, regulatory affairs, business development, and commercialization. Prior to joining Allena, Lou served as chief medical officer at Idera Pharmaceuticals, chief medical officer at Radius Health, and senior vice president at AMAG Pharmaceuticals. He began his industry career at Genzyme Corporation, where he led successful product development programs for medicines that are currently marketed in the renal and metabolic areas.

He holds an MD from Duke University, an MBA from Harvard Business School, and a BS from Yale University, He completed his residency in internal medicine at Brigham and Women’s Hospital and his fellowship in nephrology at Brigham and Women’s Hospital and Massachusetts General Hospital. Lou holds a clinical appointment at Brigham and Women’s Hospital.